What’s cold is hot again! Here’s how one facility answered all the questions and implemented trauma whole blood in 2018.

David Oh and Mike Goodman Trauma Whole Blood

Drs. David Oh and Mike Goodman

It feels like pretty much everyone is discussing cold-stored, low-titer, group O whole blood (LTOWB) today. Trauma surgeons hear about it at national and international conferences, articles are published, and people like my friend Mark Yazer champion it (see episode 040CE if you don’t believe me!). To local transfusion services, however, the discussion can be frustrating, because many clinical folks think we should be able to “turn on the faucet” and start supplying the product immediately!

Not So Simple

LTOWB (some call it “trauma whole blood” though its use is not necessarily limited to trauma) is a product that comes with lots of choices and complexities from the time of donation all the way to and beyond the time of transfusion. It’s really not as simple as just saying, “hey, we collect whole blood; here you go!” All kinds of questions arise throughout the process, including (to name a few):

  • What titer is “low-titer?”
  • Should we use a 21 day or 35 day product?
  • Do we use O pos RBCs, O neg, or both?
  • Should we leukoreduce?
  • What about CMV testing?
  • How many units should our trauma patients receive?
  • Should we give LTOWB to non-trauma patients?

This Facility Did It!

David Oh (Chief Medical Officer at Hoxworth Blood Center) and Mike Goodman (trauma surgeon at University of Cincinnati) led the charge to implement trauma whole blood at their facility in 2018. They are here to share insights, lessons learned, and practical tips.


This interview is not meant to be a recipe or a mandate! Every facility will have to make their own choices, starting with the most important one: Whether or not to even implement trauma whole blood! What David and Mike did may not be the right answer for your facility, so please don’t interpret this interview as a step-by-step guide. It’s simply a demonstration of what one facility did to successfully implement this product, and what they learned while doing so.

About My Guests:

Dr. Mike Goodman trained in general surgery at the University of Cincinnati. After a fellowship in surgical critical care at the University of Texas Health Science Center at Houston, he returned back to the University of Cincinnati, where he now serves as an Associate Professor in general surgery, trauma and surgical critical care. This position has allowed Mike to continue basic and clinical research, focusing on the relationship of coagulation to post-traumatic inflammation, especially in the setting of traumatic brain injury. Clinically, he serves as the Chair of the Transfusion Safety Committee and focuses his clinical research on the appropriate resuscitation and care of the injured patient.

Dr. David Oh is the Chief Medical Officer of Hoxworth Blood Center, where he has worked since 2017 after 13 years in California, first at the San Diego Blood Bank, followed by the Stanford Blood Center. David trained in pathology at the Cleveland Clinic, and in Blood Banking/Transfusion Medicine at the BloodCenter of Wisconsin. David has served in numerous leadership roles in the California Blood Bank Society as well as Blood Centers of America and America’s Blood Centers.

DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Neither my guests nor I have any relevant financial disclosures.

Music Credit

Music for this episode includes “Cuando te invade el temor” and “Reflejo,” both by Mar Virtual via the Free Music Archive. Click the image below for permissions and license details.
Creative Commons license and link

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