Hemolytic Disease of the Fetus and Newborn (HDFN) is not just a diagnosis from the history books! It still happens, and all involved must respond quickly. Dr. Greg Denomme guides us to better HDFN understanding and management.
In the distant past, far too many babies died because we did not understand the basic principles of what we now call “hemolytic disease of the fetus and newborn” (HDFN for short). Once the most common mechanism (anti-D formation in an Rh-negative mother impacting future D-positive babies) and the intervention to prevent its occurrence (injection of Rh Immune Globulin to prevent anti-D formation in the mother) were outlined, the incidence of fatal HDFN dropped dramatically. However, we are not out of the woods yet!
Dr. Greg Denomme, winner of the 2017 AABB Sally Frank Memorial Award, has studied HDFN and worked in maternal-fetal transfusion for decades, and he is my guest to help us understand why HDFN is still a problem today. He will outline clinical and laboratory aspects to HDFN prevention and monitoring, and discuss several cases that illustrate some pitfalls for all involved in these potentially heartbreaking cases.
Greg Denomme, PhD, FCSMLS(D) (@GregDenomme) is the Senior Director of Immunohematology and Innovation at the BloodCenter of Wisconsin and a Senior Investigator with the Blood Research Institute. He is a clinical and academic trained scientist, and has worked in transfusion medicine his entire career. Dr Denomme obtained his med tech credentials along with an ART and then a doctorate in Microbiology & Immunology, followed by two postdoctoral fellowships (Pathology & Molecular Medicine at McMaster University and platelet immunology with the Canadian Red Cross Society). He received a 5-year Medical Research Council/Canadian Blood Services Scholarship while at the University of Toronto, and his work focused on platelet antigen and blood group genetics and maternal-fetal transfusion medicine. Since moving to the BloodCenter of Wisconsin, Dr. Denomme has been leading the Immunohematology Reference Lab’s foray into molecular blood group genetics. With his team, he’s developed a donor red cell genotyping program and has expanded patient testing in molecular immunohematology.
DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Neither Dr. Denomme nor I have any relevant financial disclosures.
The images below are generously provided by Dr. Denomme.