Allergic reactions? They are SO BORING! Not so fast, my fine learners! New information suggests otherwise.

Will Savage

Dr. Will Savage

Dr. Will Savage from Harvard University joins Dr. Chaffin to discuss Allergic Transfusion Reactions (ATRs).

Allergic reactions have become pretty widely known as “nuisance reactions” to blood bankers and clinical staff (“Dang it! Another patient with hives!”), and it’s easy to think that we fully understand them. However, Dr. Savage and his colleagues (primarily from his previous position at Johns Hopkins University) have spent the last few years studying allergic reactions in-depth, and they have shown in numerous recent publications that we don’t yet fully “get it” with ATRs. In fact, what he has to say may surprise you! Dr. Chaffin says, “Speaking personally, the work that Will has been involved in (much of which is referenced in the links at the bottom of this page) has completely changed the way I look at these reactions! Yes, they are a nuisance, but they are a nuisance that really impacts patients to a much greater degree than I understood in the past.”

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DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Neither Dr. Savage nor I have any financial disclosures relevant to this presentation.

The images below are generously provided by Dr. Savage.

Savage Slide 1 - ATR Definition
Savage Slide 2 - Anaphylaxis Definition
Savage Slide 3 - What do patients think of ATRs?
Savage Slide 4 - Clinical features of ATRs
Savage Slide 5 - Short symptom duration in ATRs
Savage Slide 6 - What happens when the other part of a product that gave an ATR goes to a DIFFERENT patient? Not much!
Savage Slide 7 - Washing reduces risk of ATRs
Savage Slide 8 - How to treat anaphylaxis associated with blood transfusion
Savage Slide 9 - Managing patients who have had severe allergic (anaphylactic) reactions
Savage Slide 10 - Summary of ATRs

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