Bacterially-tainted platelet units are FAR more common than other transfusion infections! Dr. Anne Eder outlines the problem and offers solutions.
Dr. Anne Eder, adjunct Professor in the Department of Pathology and Laboratory Medicine at Georgetown University, joins Dr. Chaffin to discuss Septic Transfusion Reactions. Dr. Eder is a leader in this field, having extensively spoken and published on septic reactions while serving as Executive Medical Officer, Biomedical Services at the American Red Cross. Dr. Eder believes that septic transfusion reactions are under-reported, but she also feels that blood centers have made significant progress in their prevention. In this episode, Dr. Eder discusses the ways that blood centers limit and detect bacterial contamination of apheresis platelet products, signs and symptoms of septic transfusion reactions, and how transfusion services and clinicians can work together for early diagnosis and treatment of these potentially deadly reactions.
A couple of notes
This episode was recorded on March 15, 2016, and was as up-to-date as possible on the day of recording. However, the FDA has since released draft guidance documents that could potentially “change the game” in regard to everything we do to prevent septic reactions from platelet transfusion. Please check FDA and AABB sources for current information in the United States.
Dr. Eder is now working for the Food and Drug Administration; this interview occurred before her employment there, and should not be construed in any way to reflect official FDA policy.
BONUS: Early in the interview, Dr. Eder also gave a great summary of where we were with Zika virus safety measures for prevention of this virus entering the U.S. blood supply. For more information, see Episode 15.
DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated (currently or when this interview occurred in 2016). Neither Anne nor I have any relevant financial disclosures.
The images below are referenced in Dr. Eder’s discussion. Please click on an image to see a larger version, or click here for the full handout, courtesy of Dr. Eder.