Molecular (genetic) testing is everywhere in medicine today, and the blood bank is no exception! You don’t have to be a geneticist to see how it all fits, however. I’m happy to have Dr. Meghan Delaney here to present:
7 practical uses for molecular testing in transfusion medicine.
You can hardly turn around in health care today without hearing someone talking about genetic testing (just to confuse people, such testing is more formally known as “molecular diagnostics” or “molecular testing”). In the blood bank, molecular testing is available right now, and it can really impact our day-to-day practice.
Fortunately for us, Meghan Delaney works right on the cutting edge of molecular testing. Her unique experience (she oversees both a hospital transfusion service and an AABB-accredited immunohematology reference lab) allows her a great perspective on who should be using this testing and how it all fits together. This is a really enlightening discussion that may just open your eyes to some new possibilities!
Meghan Delaney is an Associate Professor in the Department of Laboratory Medicine and Pediatrics at the University of Washington, Medical Director for the Immunohematology & Red Cell Genomics Reference Laboratory at Bloodworks Northwest, and Medical Director of the transfusion service at Seattle Children’s Hospital. She also focuses on transfusion improvement and medical education and sustainable technology development in developing nations. Dr. Delaney chairs or serves on multiple committees for AABB, ASFA, and CAP. She is an Associate Editor for the journal Transfusion Medicine, and is on the editorial board of Transfusion. She is an Associate Scientific Member of the BEST Collaborative and the Associate Program Director for the Pathology Residency Program at University of Washington.
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DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Neither Dr. Delaney nor I have any relevant financial disclosures.
The images below are generously provided by Dr. Delaney.
- Sickle Cell Alloimmunization Despite Matching: Chou ST et al. High prevalence of red blood cell alloimmunization in sickle cell disease despite transfusion from Rh-matched minority donors. Blood 2013 122:1062-1071.
- Low Incidence of Alloimmunization in D Variant Recipients: Yazer MH et al. Low incidence of D alloimmunization among patients with a serologic weak D phenotype after D+ transfusion. Transfusion 2016;56;2502–2509.
- Survey of WAA Practices: Ziman A et al. Warm-reactive (immunoglobulin G) autoantibodies and laboratory testing best practices: review of the literature and survey of current practice. Transfusion 2017;57;463–477.