Neonatal alloimmune thrombocytopenia (NAIT), the disease with many names, continues to confound blood bankers everywhere! The conversation goes like this: “This baby has a low platelet count…is it NAIT?” Answer: “Ummmm….” I’m not meaning to offend anyone in transfusion service-world, because obviously, there are experts on this topic out there! Fortunately for us, I happen to have interviewed one of those experts for this podcast episode! Dr. Brian Curtis oversees one of the the world’s foremost labs for platelet antigen/antibody testing, and he explains how to take the right steps to find the answer, both in the real world and the exam world.
DISCLAIMER: The opinions expressed on this episode are those of my guest and I alone, and do not reflect those of the organizations with which either of us is affiliated. Dr. Curtis wants you to know that he has done research for Prophylix, the Norwegian company mentioned in the episode that is attempting to bring a medication to market to prevent NAIT. I (Dr. Chaffin) have no relevant disclosures.
The images below are generously provided by Dr. Curtis.
- Peterson JA, McFarland JG, Curtis BR, and Aster, RH. Neonatal alloimmune thrombocytopenia: pathogenesis, diagnosis and management. British Journal of Haematology 2013;161:3–14. (Offered free at time of this podcast).
- Kamphuis MM et al. Incidence and Consequences of Neonatal Alloimmune Thrombocytopenia: A Systematic Review. Pediatrics 2014;133;715-21. (Offered free at time of this podcast).
- Pacheco LD et al. Fetal and Neonatal Alloimmune Thrombocytopenia: A Management Algorithm Based on Risk Stratification. Obstetrics & Gynecology 2011;118(5):1157-1163.
- Espinoza JP et al. Fetal and Neonatal Alloimmune Thrombocytopenia. Rev Obstet Gynecol 2013;6(1):e15-e21.
- Australian Red Cross NAIT Info Page.