PF24 stands for “Plasma frozen within 24 hours after phlebotomy,” and is also known as “FP24” (which reads easier because it compares nicely to “FFP” but isn’t really the official term). In the US, this product can be made from either whole blood or apheresis collection (note the contrast to PF24’s similar-sounding sibling “PF24RT24“. PF24 differs from “fresh frozen plasma” (FFP) in a very specific way:

  • FFP:
    • In freezer (at < -18C) within 8 hours of collection
  • PF24:
    • In refrigerator (at 1-6C) within 8 hours of collection
    • In freezer (at < -18C) within 24 hours of collection

The up to 16-hour difference in freezer placement between the two products leads to mild to moderate decreases in the “labile coagulation factors” in PF24. As expected, there is some decrease in factor VIII (FVIII) when compared to FFP, but the levels of factor V (FV) are not significantly different between the two products in many studies (there is also a significant decrease in the clotting inhibitor Protein C in PF24). Theoretically, PF24 should not be used in clinical situations where a patient has a deficit of either FV or FVIII, but in reality, the two plasma products are used interchangeably. At this time, PF24 CAN’T be used to make Cryoprecipitate (due to decreased levels of FVIII), but like FFP, it can be relabeled as Thawed Plasma.

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