- In freezer (at < -18C) within 8 hours of collection
- In refrigerator (at 1-6C) within 8 hours of collection
- In freezer (at < -18C) within 24 hours of collection
The up to 16-hour difference in freezer placement between the two products leads to mild to moderate decreases in the “labile coagulation factors” in PF24. As expected, there is some decrease in factor VIII (FVIII) when compared to FFP, but the levels of factor V (FV) are not significantly different between the two products in many studies (there is also a significant decrease in the clotting inhibitor Protein C in PF24). Theoretically, PF24 should not be used in clinical situations where a patient has a deficit of either FV or FVIII, but in reality, the two plasma products are used interchangeably. At this time, PF24 CAN’T be used to make Cryoprecipitate (due to decreased levels of FVIII), but like FFP, it can be relabeled as Thawed Plasma.
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