Liquid Plasma

Never-frozen blood product composed of plasma separated from whole blood at any time from collection up to 5 days after the whole blood unit expires. Note that the product may only be transfused up to the same date: 5 days after the whole blood expiration date. Since whole blood is typically collected in CPD or CP2D anticoagulant/preservative solution with a 21 day shelf life in the U.S., Liquid Plasma typically has a maximum shelf life of 26 days and is stored refrigerated at 1-6C. Though the quantity of certain coagulation factors (especially Factor V and Factor VII) decline in a plasma product stored for this length of time, sufficient quantities remain to be useful as a starting point in urgent situations. Liquid Plasma does not need to be thawed (obviously) prior to transfusion, so it can be quite useful in “the initial treatment of patients who are undergoing massive transfusion” (Circular of Information for the Use of Human Blood and Blood Components, November 2013, page 21). Growing numbers of trauma centers are using Liquid Plasma as a “bridge” to a thawed plasma component such as Fresh Frozen Plasma or PF24.

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