Quiz: Non ABO/Rh Blood Groups

1. Which of the following phenotypes is seen MORE frequently in those of European descent than in those of African descent?

Fy(a-b-) phenotype

S-s-U phenotype

R0 haplotype

K+k+ phenotype

Le(a-b-) phenotype

2. A person with which one of the following red cell phenotypes is expected to be resistant to Plasmodium vivax malaria?

Fy(a-b-) phenotype

Rh_null phenotype

McLeod phenotype

S-s-U- phenotype

Le(a-b-) phenotype

3. Which of the following red blood cell antigens shows increased expression following incubation with proteolytic enzymes?

Duffy antigens

MN antigens

Kidd antigens

Kell antigens

Lutheran antigens

4. You are told that a patient has the "McLeod Syndrome." Which of the following is most likely to be TRUE regarding the patient?

The patient is susceptible to Streptococcus infections

The patient has stomatocytes in his peripheral blood smear

The patient has increased levels of Kell blood group antigens

The patient presents with seizures or involuntary movements

The patient has an increased level of Kx antigen in his blood

5. Which of the following lectins is matched appropriately with its target antigen?

Vicea graminea: N antigen

Dolichos biflorus: H antigen

Salvia: A2 antigen

Ulex europaeus: A1 antigen

Ulex europaeus: Sd^a antigen

6. Which of the following red cell antigens is fully and strongly expressed on red blood cells from a term neonate?

I antigen

K antigen

A antigen

Le^a antigen

P1 antigen

7. Which of the following is TRUE about the I blood group system?

Auto-anti-i is associated with Mycoplasma pneumonia

Auto-anti-I is associated with infectious mononucleosis

i antigen is stronger on adult RBCs than neonatal RBCs

Patients with auto-anti-I may require a "prewarmed" crossmatch before transfusion

Antibodies in this system are usually clinically significant

8. Which of the following is TRUE of the P1PK and GLOB blood group systems?

The P antigen is the point of entry of Plasmodium vivax into the red cell

Anti-P1 is a common cause of hemolytic disease of the fetus/newborn

Anti-P1 is an insignificant antibody neutralized by pigeon egg white fluid

The lack of antigens in these systems may lead to the McLeod syndrome

Antibodies against these antigens are not associated with hemolytic transfusion reactions

9. A 5 year old child had an upper respiratory infection 5 days ago. Today, his mother brings him to the emergency room because his urine was bright red this morning. Upon admission, he appears pale, his hemoglobin is 6.4 g/dL, his urine and serum have free hemoglobin, and his direct antiglobulin test (DAT) is weakly positive with anti-C3 only (anti-IgG is negative). Which of the following is most likely TRUE?

This child has Paroxysmal Nocturnal Hemoglobinuria

The antibody specificity is most likely anti-P

The child should be tested for syphilis

Transfusion should wait until antigen-negative blood is available

The antibody is most likely a high-titer IgM antibody

The diagnostic test is the "Donath-Wiener" test

Non-ABO/Rh Blood Groups Quiz

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Answers and explanations are presented at the end of the quiz.

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