Education

Febrile Nonhemolytic Reactions

The Febrile Nonhemolytic Transfusion Reaction (FNH for short) is, by all accounts, one of the most common reactions seen today, though some recent interventions seem to be decreasing their frequency somewhat.

With the familiarity of being common, though, comes the danger of complacency. It's very easy, after seeing about a bazillion of these things, to fall into the trap of thinking that you can diagnose them every time without a workup or any investigation whatsoever. If you thought that, YOU WOULD BE WRONG!! If that is not clear by now, please see the sections on fever during transfusion and acute hemolytic reactions.

Recent research has shed new light on these reactions, and we'll try to get you up to speed in the following sections, covering the presentation, diagnosis, pathophysiology, treatment, and prevention of the FNH.

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